Fig 2. Overall summary of identified mutant variants.

(A) Statistically significant hits based on a signal-to-noise ratio cutoff of 2, at least two reported cases, and a P value cutoff of 0.062 based on the first quartile of adjusted P values from the analyses of all exact matches in nonexpressed genes (see methods). The number of input exomes for given tumor type is indicated at the top of the heatmap. (B) Highlights of hits with significance in at least two tumor types, genes involved in Ras/mitogen-activated protein kinase pathways and Noonan syndrome.