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. 2016 Jun 15;11(6):e0156852. doi: 10.1371/journal.pone.0156852

Fig 11. Xenin-25 profoundly increases PP release in humans with NG, IGT, and T2DM.

Fig 11

(A) PP levels were measured at the indicated times in subjects with NGT during meal tolerance tests with albumin alone (Alb; blue dots) or xenin-25 at a dose of 4 pmol/kg/min (Lo-Xen; yellow squares) or 12 pmol/kg/min (Hi-Xen; red triangles). As in the bethanechol study, the liquid meal was ingested from 0–3 min. (B) 0–300 min AUCs for data in panel A are shown. (C-E) PP levels were measured in the samples collected before (0 min) and 30 min after meal ingestion in humans with NGT (Panel C), IGT (Panel D), and T2DM (Panel E) during a primed-continuous infusion of xenin-25 (12 pmoles/kg/min).