Table 3. Biochemical and enzymatic analysis of blood from female BALB/c mice after treatment with AmB, MFLB-AmB, and MFLB for 30 or 60 days.
| Groups | Urea(mg/DL) | Creatinine (mg/DL) | AST (UI/L) | ALT (UI/L) | Transferrin | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| 30 days | 60 days | 30 days | 60 days | 30 days | 60 days | 30 days | 60 days | 30 days | 60 days | |
| NC | 49 ±7.4 | 57±6.6C,B | 0.22±0.1 | 0.22±0.05 | 101±20.28A | 83±3.31A | 7±2.2 | 12.25±1.70 | 222±2.38B | 220±3.7 |
| PC | 48±3.5 | 48±5.7C | 0.3±0.1 | 0.23±0.05 | 128±24.84A,B | 71±0.57B | 10±1.6 | 6.66±2.51 | 227±3.60A,B | 217±10.5 |
| AmB | 62±9 | 61±4.0B | 0.24±0.1 | 0.23±0.11 | 133±22.65A,B | 85±8.00A,B | 10±0.8 | 10.33±2.51 | 225±12.9A,B | 233±5.5 |
| MFLB-AmB | 53±8.7 | 79±1.0A | 0.27±0.05 | 0.30±0 | 97±16.34A,B | 114±2.30A,B | 9±3.2 | 10.00±0 | 234±4.12A | 232±0.6 |
| MFLB | 60±5.6 | 43±1.5D | 0.30±0 | 0.30±0 | 69±0.57B | 91±20.51A,B | 12±1.7 | 9.66±0.57 | 226±5.85A,B | 227±10.2 |
NC Group = animals uninfected; Positive Control, MFLB, AmB and MFLB-AmB Groups = animals infected with Paracoccidoides brasiliensis; AmB = amphotericin B; MFLB-AmB = nanosized magnetite surface-functionalized with a bilayer of lauric acid conjugated with amphotericin B; MFLB = nanosized magnetite surface-functionalized with a bilayer of lauric acid
Different letters denote significant differences between treatments (Tukey, p < 0.05) inside the same column. Treatments without lettering are not significantly different inside the same column.