Table 1. A 72-member constrained gene subnetwork.
Gene | Constraint score | Chr | Start | End | Gene | Constraint score | Chr | Start | End |
---|---|---|---|---|---|---|---|---|---|
DYNC1H1 | 9.977 | 14 | 101964528 | 102050792 | UBR4 | 4.940 | 1 | 19074506 | 19210276 |
PRPF8 | 8.302 | 17 | 1650629 | 1684882 | CHD3 | 4.905 | 17 | 7884806 | 7912760 |
HUWE1 | 7.973 | X | 53532096 | 53686729 | USP7 | 4.866 | 16 | 8892094 | 8964514 |
SMARCA4 | 6.604 | 19 | 10961001 | 11065395 | PRPF6 | 4.826 | 20 | 63981135 | 64033100 |
POLR2A | 6.578 | 17 | 7484366 | 7514618 | GNAS | 4.806 | 20 | 58839718 | 58911192 |
RYR2 | 6.436 | 1 | 237042205 | 237833988 | THOC2 | 4.791 | X | 123600561 | 123733056 |
MED12 | 6.388 | X | 71118556 | 71142454 | FRY | 4.772 | 13 | 32031300 | 32299122 |
SNRNP200 | 6.166 | 2 | 96274336 | 96305515 | OGT | 4.753 | X | 71533083 | 71575897 |
CHD4 | 6.162 | 12 | 6570083 | 6607476 | POLR2B | 4.729 | 4 | 56977722 | 57031168 |
MTOR | 5.974 | 1 | 11106535 | 11262507 | KCNMA1 | 4.687 | 10 | 76869601 | 77638595 |
GRIN1 | 5.971 | 9 | 137138390 | 137168762 | TAOK1 | 4.685 | 17 | 29390464 | 29551904 |
PPFIA3 | 5.794 | 19 | 49119389 | 49151026 | BRWD3 | 4.683 | X | 80670854 | 80809688 |
MLL | 5.747 | 11 | 118436490 | 118526832 | SPTAN1 | 4.671 | 9 | 128552558 | 128633665 |
UBR5 | 5.720 | 8 | 102253012 | 102412841 | PHIP | 4.670 | 6 | 78935867 | 79078236 |
ITPR1 | 5.589 | 3 | 4493348 | 4847840 | DDB1 | 4.670 | 11 | 61299451 | 61342596 |
CLTC | 5.547 | 17 | 59619689 | 59696956 | HSPA2 | 4.665 | 14 | 64535905 | 64546173 |
FLNA | 5.541 | X | 154348524 | 154374638 | SPEG | 4.644 | 2 | 219434846 | 219498287 |
UPF1 | 5.514 | 19 | 18831938 | 18868236 | SMC3 | 4.639 | 10 | 110567691 | 110604636 |
HCFC1 | 5.450 | X | 153947553 | 153971807 | MYH10 | 4.629 | 17 | 8474205 | 8630761 |
DHX30 | 5.428 | 3 | 47802909 | 47850195 | XPO1 | 4.621 | 2 | 61477849 | 61538626 |
SPTBN1 | 5.423 | 2 | 54456285 | 54671445 | CUL3 | 4.610 | 2 | 224470150 | 224585397 |
SF3B1 | 5.418 | 2 | 197389784 | 197435091 | IRS2 | 4.592 | 13 | 109752698 | 109786568 |
SMARCA2 | 5.387 | 9 | 2015219 | 2193624 | ADCY1 | 4.587 | 7 | 45574140 | 45723116 |
CACNA1I | 5.363 | 22 | 39570753 | 39689737 | APC2 | 4.564 | 19 | 1446302 | 1473244 |
SMC1A | 5.360 | X | 53374149 | 53422728 | ZBTB17 | 4.547 | 1 | 15941869 | 15976132 |
GRIN2B | 5.334 | 12 | 13537337 | 13980119 | TLN1 | 4.517 | 9 | 35696948 | 35732395 |
GRIN2D | 5.211 | 19 | 48394875 | 48444931 | MYH9 | 4.496 | 22 | 36281281 | 36388018 |
TAF1 | 5.178 | X | 71366239 | 71532374 | EEF2 | 4.478 | 19 | 3976056 | 3985469 |
VCP | 5.162 | 9 | 35056064 | 35073249 | PDS5A | 4.451 | 4 | 39822863 | 39977956 |
CNOT1 | 5.146 | 16 | 58519951 | 58629886 | PRKD2 | 4.438 | 19 | 46674275 | 46717127 |
TRIO | 5.109 | 5 | 14143702 | 14532128 | BRD4 | 4.436 | 19 | 15235519 | 15332545 |
CYFIP2 | 5.100 | 5 | 157266079 | 157395598 | HSPA8 | 4.364 | 11 | 123057489 | 123063230 |
SUPT5H | 5.065 | 19 | 39436156 | 39476670 | CTNNB1 | 4.198 | 3 | 41194837 | 41260096 |
FZD8 | 5.028 | 10 | 35638249 | 35642278 | UBC | 3.997 | 12 | 124911604 | 124917368 |
TNPO2 | 4.993 | 19 | 12699194 | 12724011 | PIK3CD | 3.858 | 1 | 9651732 | 9729114 |
GTF2I | 4.945 | 7 | 74657667 | 74760692 | PIK3R1 | 2.170 | 5 | 68215720 | 68301821 |