Table 3. The 72-member constrained gene subnetwork is preferentially expressed in a range of tissues and brain structures.
Source | Tissue | Developmental stage | Permutation p-value | Resampled p-value | Tissue-specific genes |
---|---|---|---|---|---|
REP | CD34+ | Perinatal (cord blood) | 0.00100 | 0.00100 | 10 |
REP | Fetal brain | Fetal | 0.01100 | 0.00100 | 16 |
REP | CD8+ | Adult (>20 years) | 0.01700 | 0.00100 | 10 |
REP | Fetal thymus | Fetal | 0.04800 | 0.00100 | 5 |
BrainSpan | Caudal ganglionic eminence | 2A (8–9 pcw) | 0.00125 | 0.00125 | 20 |
BrainSpan | Dorsolateral prefrontal cortex | 2A (8–9 pcw) | 0.00125 | 0.00125 | 16 |
BrainSpan | Hippocampal anlage | 2A (8–9 pcw) | 0.00125 | 0.00125 | 17 |
BrainSpan | Lateral ganglionic eminence | 2A (8–9 pcw) | 0.00125 | 0.00125 | 19 |
BrainSpan | Primary motor-sensory cortex | 2A (8–9 pcw) | 0.00125 | 0.00125 | 20 |
BrainSpan | Medial frontal cortex | 2A (8–9 pcw) | 0.00125 | 0.00125 | 19 |
BrainSpan | Orbital frontal cortex | 2A (8–9 pcw) | 0.00250 | 0.00125 | 14 |
BrainSpan | Parietal neocortex | 2A (8–9 pcw) | 0.00250 | 0.00125 | 18 |
BrainSpan | Medial ganglionic eminence | 2A (8–9 pcw) | 0.00375 | 0.00125 | 18 |
BrainSpan | Occipital neocortex | 2A (8–9 pcw) | 0.00500 | 0.00125 | 18 |
BrainSpan | Hippocampus | 2B (10–12 pcw) | 0.00625 | 0.00125 | 18 |
BrainSpan | Hippocampus | 3A (13–15 pcw) | 0.00625 | 0.00125 | 19 |
BrainSpan | Primary somatosensory cortex | 3A (13–15 pcw) | 0.01250 | 0.00125 | 20 |
BrainSpan | Primary visual cortex | 4 (19–24 pcw) | 0.01750 | 0.00125 | 22 |
BrainSpan | Posterior superior temporal cortex | 3B (16–18 pcw) | 0.01875 | 0.00125 | 22 |
BrainSpan | Posteroventral parietal cortex | 3A (13–15 pcw) | 0.02250 | 0.00125 | 19 |
BrainSpan | Cerebellar cortex | 4 (19–24 pcw) | 0.02500 | 0.00125 | 19 |
BrainSpan | Primary motor cortex | 3A (13–15 pcw) | 0.02750 | 0.00125 | 19 |
BrainSpan | Striatum | 3A (13–15 pcw) | 0.04125 | 0.00125 | 17 |
BrainSpan | Dorsolateral prefrontal cortex | 4A (19–24 pcw) | 0.04625 | 0.00250 | 21 |