Table 1. Dark-adapted (scotopic) retinal light responses (Data for Fig 2A, 2B and 2E).
| Light Intensity cd·s/m2 | WT-Normal | WT-HFD | miR-150-/--Normal | miR-150-/--HFD |
|---|---|---|---|---|
| Scotopic a-wave amplitude (μV) | ||||
| 0.1 | 56.5±7.0 | 42.6±5.6 | 46.6±8.5 | 29.1±4.4 * |
| 0.3 | 100.8±9.7 | 76.1±7.8 | 90.6±14.0 | 64.1±7.0 * |
| 1 | 124.2±10.5 | 91.3±6.7 | 103.8±13.0 | 80.2±6.6 * |
| 3 | 139.3±11.4 | 105.8±8.3 | 115.5±12.6 | 109.2±20.9 |
| 10 | 197.7±13.6 | 145.9±13.2 | 179.6±18.7 | 126.4±11.4 * |
| 25 | 206.2±14.1 | 175.6±13.9 | 187.3±18.5 | 131.2±7.9 *, # |
| Scotopic b-wave amplitude (μV) | ||||
| 0.1 | 375.3±22.9 | 339.9±34.1 | 383.9±48.8 | 258.3±22.4 *, # |
| 0.3 | 456.8±24.0 | 352.3±27.8 | 459.2±50.8 | 327.7±23.4 *, # |
| 1 | 481.7±24.5 | 392.3±31.2 | 482.8±48.5 | 353.6±21.9 *, # |
| 3 | 498.4±26.8 | 404.1±32.7 | 488.4±45.7 | 356.0±18.0 *, # |
| 10 | 582.8±29.4 | 456.0±39.1 | 603.7±55.7 | 415.5±28.2 *, # |
| 25 | 588.7±32.4 | 478.8±38.0 | 611.0±54.3 | 415.7±23.6 *, # |
| Scotopic Oscillatory Potentials: ƩOP (1–4) amplitude (μV) | ||||
| 0.1 | 266.2±12.9 | 193.4±19.7^ | 197.6±13.8 | 207.2±17.6^ |
| 0.3 | 316.3±11.8 | 211.0±21.5^ | 326.9±16.3 | 248.3±11.4^ |
| 1 | 296.9±14.0 | 240.5±19.1 | 297.8±23.0 | 249.8±18.4 |
| 3 | 261.4±20.4 | 218.2±19.0 | 262.34±24.5 | 220.0±16.8 |
| 10 | 368.9±13.9 | 288.3±16.5^ | 369.5±14.3 | 301.7±7.1^ |
| 25 | 374.7±15.7 | 312.1±14.6^ | 364.0±16.24 | 308.9±12.0^ |
Scotopic ERG a-wave:
* denotes miR-150-/—HFD significantly different from WT-Normal.
# denotes miR-150-/—HFD significantly different from miR-150-/—Normal.
There is a significant difference between mice with normal chow (both WT and miR-150-/-) and HFD-mice (both WT and miR-150-/-), indicating the impact of HFD on the scotopic ERG a-wave.
There is a significant difference between WT (both normal chow and HFD) and miR-150-/-, indicating the impact of miR-150 null mutation on the scotopic ERG a-wave.
Scotopic ERG b-wave:
* denotes miR-150-/--HFD significantly different from WT-Normal.
# denotes miR-150-/--HFD significantly different from miR-150-/--Normal.
There is a significant difference between mice with normal chow (both WT and miR-150-/-) and HFD-mice (both WT and miR-150-/-), indicating the impact of HFD on the scotopic ERG b-wave.
Scotopic ERG Oscillatory Potentials:
^ denotes both WT-HFD and miR-150-/—HFD significantly different from both WT-Normal and miR-150-/—Normal, indicating the impact of HFD on scotopic ERG OPs.