Fig. 4.

Neuroplastic structural changes following one month of intervention with the Continuous Positive Airway Pressure or Best Supportive Care treatment.

Potential strengthening in interregional connectivity between the non-dominant thalamus with hippocampus and (or) cerebellar cortex in OSA patients was noted only in CPAP treated group (first row). In addition, in the same group of patients, improvement in sleepiness (as shown by the ESS), was strongly positively correlated to changes occurring in brainstem during this period (second row).