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Implication of DNA damage repair deficits in ATRX-deficient glioma for clinical practice. Schematic showing how improved understanding of the role of ATRX mutation in human glioma could be integrated into personalized therapy. ATRX mutation is associated with loss of ATRX by immune staining, which is increasingly used in neuropathological assessment of human gliomas. ATRX, α thalassemia/mental retardation syndrome X-linked; SNV, single nucleotide variant.
