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Modification pathway for mcm5s2U34- and m5C34-containing tRNAs. A. Proteins required for mcm5 modification (left) and s2 modification (right) of U34. Acetyl-CoA acts as a donor for cm5 modification, and SAM as a methyl donor to form mcm5U34. For s2 modification, cysteine acts as sulfur donor. Modified side groups are shown in red. B. Trm4p catalyzed cm5C34 modification where SAM acts as a methyl donor. Modified side group is shown in red.
