Human neutrophil peptides (HNPs) induce leukocyte adhesion mediated by low-density lipoprotein receptor (LDLR)–related protein 8 (LRP8) in vivo. A and B, Leukocyte rolling in carotid artery was monitored by intravital microscopy in wild-type (WT) mice 4 hours after receiving intravenous injection of vehicle (V) or HNPs (10 mg/kg). C, Mean values of leukocyte rolling in WT, LRP8−/−, or LDLR−/−/LRP−/− mice 4 hours after injection with HNPs. D and E, Mean plasma levels of HNPs and myeloperoxidase (MPO) activity measured in WT, LRP8−/−, or LDLR−/−/LRP−/− mice 4 hours after injection with HNPs. *P<0.05 vs V under identical conditions, †P<0.05 vs WT under identical conditions.