Table 1.
Demographics and clinical characteristics of the patients with bipolar I disorder and the referent subjects at baseline.
| Bipolar I disorder | Referent subjects | OR (95% CI) | p | |
|---|---|---|---|---|
| Demographics | ||||
| Age at index date – median, IQR | 37 (28, 52) | 37 (28, 52) | 0.91 | |
| Sex (women) – n, % | 173 (52) | 173 (52) | 1.00 (0.74,1.36) | >0.99 |
| Education | 0.43 | |||
| High school graduate or less – | 128 (38) | 144 (43) | 1.00 (Ref) | |
| Some college – n, % | 60 (18) | 75 (22) | 0.89 (0.59, 1.36) | |
| Complete college or more – n, | 82 (25) | 73 (22) | 1.26 (0.85, 1.86) | |
| Marital status | <0.01 | |||
| Married – n, % | 145 (43) | 222 (66) | 1.00 (Ref) | |
| Single – n, % | 111 (33) | 71 (21) | 2.39 (1.66, 3.44) | |
| Divorced/separated – n, % | 63 (19) | 19 (6) | 5.08 (2.92, 8.83) | |
| Widowed – n, % | 14 (4) | 18 (5) | 1.19 (0.57, 2.47) | |
|
| ||||
| Clinical features | ||||
| Alcohol use disorder – n, % | 80 (24) | 15 (5) | 6.70 (3.77, 11.9) | <0.01 |
| Drug use disorder – n, % | 50 (15) | 4 (1.2) | 14.5 (5.2, 40.7) | <0.01 |
| Anxiety disorders – n, % | 7 (2.1) | 5 (1.5) | 1.4 (0.44, 4.5) | 0.56 |
|
| ||||
| CVD risk factors | ||||
| BMI – median (IQR) | 25.2 (22.3, 28.9) | 25.0 (22.3, 28.1) | 0.49 | |
| Obesity – n, % | 58 (19) | 59 (19) | 0.99 (0.66, 1.48) | 0.95 |
| Diabetes – n, % | 22 (6.6) | 11 (3.3) | 2.1 (0.98, 4.34) | 0.05 |
| Hypertension – n, % | 47 (14) | 26 (7.8) | 1.94 (1.17, 3.21) | 0.01 |
| Hyperlipidemia – n, % | 21 (6.3) | 16 (4.8) | 1.34 (0.68, 2.61) | 0.39 |
| Smoking | 0.01 | |||
| Never smoker – n, % | 114 (36) | 144 (45) | 1.00 (Ref) | |
| Former smoker – n, % | 63 (20) | 77 (24) | 1.03 (0.68, 1.56) | |
| Current smoker – n, % | 136 (44) | 100 (31) | 1.71 (1.20, 2.45) | |
IQR: interquartile range. DSM: Diagnostic and Statistical Manual for Mental Disorders. SD: standard deviation. BMI: body mass index.