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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Cell Biochem. 2016 Jan 21;117(8):1813–1821. doi: 10.1002/jcb.25481

Figure 6. Schematic diagram showing role of Bag5 in unfolded protein response in cardiomyocytes.

Figure 6

Bag5 protein interacts with GRP78 and regulates the downstream signaling of UPR. Expression of Bag5 regulates the expression of GRP78 sXBP1 but other signaling ER signaling ATF4, ATF6, does not change. Interestingly, in ER stress it is found that Bag5 and GRP78 protein interaction increased suggests that Bag5 protein is a one of the regulator of GRP78 function. Importantly, expression of Bag5 protein reduces the ER stress induced CHOP protein expression and attenuated the cell death.