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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: J Am Chem Soc. 2016 Jun 2;138(23):7353–7364. doi: 10.1021/jacs.6b02960

Figure 6.

Figure 6

Inhibition of CRABP2/RARα target gene induction by probe 4. (a) mRNA transcript levels of the RA signaling target gene CRBP1 as measured by qPCR in MCF-7 cells. MCF-7 cells in charcoal-treated FBS were pretreated with 20 µM 4 or DMSO for 4 h and subsequently treated with 100µM RA or EtOH for 24 h. (b-c) mRNA transcript levels of CRABP2 (b) and FABP5 (c) in MCF-7 cells treated under the same conditions as in (a). Error bars show SEM (n = 4). *p < 0.05, **p < 0.01, ***p < 0.001.