Table 1.

Summary results for newly identified genetic risk variants associated with colorectal cancer risk at P < 5.0 ×10⁻⁸ East-Asian descendants

SNP	Locus	Genea	Positionb	Allelesc	EAFd	Discoverye		Replicatione		Combinede		Heterogeneity
						8,027 cases /22,577 controls		11,044 cases/12,047controls		19,071 cases /34,624 controls
						OR (95% CI)e	Pe	OR (95% CI)e	Pe	OR (95% CI)e	Pe	I2	Pf
rs4711689	6p21.1	TFEB	41692812	A/G	0.85	1.12 (1.06–1.18)	3.41×10−5	1.10 (1.05–1.16)	2.89×10−4	1.11 (1.07–1.15)	3.92×10−8	31	0.13
rs2450115	8q23.3	EIF3H	117624093	T/C	0.58	1.11 (1.06–1.17)	9.19×10−6	1.11 (1.07–1.16)	2.94×10–8	1.12 (1.09–1.15)	1.24×10−12	0	0.51
rs6469656	8q23.3	EIF3H	117647788	A/G	0.67	1.12 (1.07–1.16)	2.59×10−7	1.10 (1.06–1.15)	1.55×10−6	1.11 (1.08–1.14)	2.03×10−12	38	0.07
rs4919687	10q24.3	CYP17A1	104595248	G/A	0.80	1.16 (1.09–1.24)	7.52×10−6	1.13 (1.08–1.19)	1.91×10−7	1.14 (1.10–1.19)	7.82×10−12	0	0.48
rs10506868	10q25.2	VTI1A	114319380	T/C	0.28	1.09 (1.04–1.14)	1.00×10−4	1.10 (1.05–1.14)	9.25×10−6	1.10 (1.06–1.13)	3.98×10−9	0	0.84
rs11064437	12p13.3	SPSB2	6982162	C/T	0.75	1.14 (1.09–1.20)	2.80×10−7	1.10 (1.05–1.15)	2.11×10−5	1.12 (1.08–1.16)	4.48×10−11	52.5	0.03
rs6061231	20q13.3	RPS21	60956917	C/A	0.91	1.19 (1.12–1.27)	8.56×10−8	1.18 (1.07–1.28)	2.20×10−4	1.18 (1.13–1.25)	8.04×10−11	0	0.47

EAF, effect allele frequency; OR, odds ratio; CI, confidence interval.

^aThe closest gene.

^bThe chromosome position (bp) is based on the National Center for Biotechnology Information (NCBI) database, build 37.

^cEffect/reference alleles are based on forward allele coding in NCBI, build 37. OR and 95% CI were estimated based on the effect allele (bold).

^dEAF in controls from all studies combined.

^eSummary OR (95% CI) and P were obtained from a fixed-effects meta-analysis.

^fP for heterogeneity across all studies was calculated using Cochran’s Q test.