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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2016 May 1;7(4):527–557. doi: 10.1002/wrna.1355

Figure 5. Tdrd7 and Stau1 granules in mouse lens development.

Figure 5

(A) Tdrd7 protein is localized to cytoplasmic granules in lens fiber cells of mouse at embryonic day (E) 12.5. (A’) Broken line denoted area in “A” is shown at high magnification. Deficiency of Tdrd7, a Lotus/OST-HTH and tudor domain protein and RNA granule (RG) component, in human and mouse causes cataracts and glaucoma. (B) Stau1 cytoplasmic granules are observed in lens fiber cells at E12.5. (B’) Broken line denoted area in “B” is shown at high magnification. Stau1 (Staufen 1), a double stranded RBP and RG component, functions in the localization of mRNA in oocytes and neurons. Scale bar in A, B is 25 μm; in A’, B’ is 5 μm.