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Linewidth dependence of the NAD resonance pattern at 4 T. Model simulations of NAD+ quartet (bottom), NADH singlet (middle) and combined NAD resonance (top) with predetermined NAD+/NADH redox ratio (RX) of 4.8 are displayed as the α-ATP HLW increasing from 3.5 Hz (a), 6 Hz (b), 7.8 Hz (c) for mimicking in vivo 1H-decoupled 31P spectrum, to 10.5 Hz (d) for mimicking in vivo 1H-coupled 31P spectrum.
