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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Acta Physiol (Oxf). 2016 Jan 4;219(1):188–201. doi: 10.1111/apha.12642

Table 2.

Chemical structures of trioxilin and hepoxilin analogs and their effect on relaxation at a concentration of 3 μM on mesenteric arteries constricted with U46619.

Eicosanoid Chemical Structure Log EC50 (M) Relaxation at 3 μM (%)
Trioxilin A3 graphic file with name nihms745547t1.jpg −5.90 78.9±3.2
Trioxilin B3 graphic file with name nihms745547t2.jpg −5.15 29.7±4.6
Trioxilin C3 graphic file with name nihms745547t3.jpg −6.00 82.2±5.0
Hepoxilin A3-ether graphic file with name nihms745547t4.jpg −5.99 88.0±2.4
11(R),12(S)-Hepoxilin A3 graphic file with name nihms745547t5.jpg −5.14 (−4.93) 20.0±5.1 (10.4±4.3)
11(S),12(R)-Hepoxilin A3 graphic file with name nihms745547t6.jpg −5.20 (−4.66) 27.8±6.3 (7.1±3.3)

Values represent Mean ± SEM (n=8). Values in parenthesis were determined in the presence of 1μM AUDA. Log EC50 represents concentration that causes 50% of the maximum response.