Table 2.
Comparative analysis of the toxicity of docetaxel: original drug versus generics
| Toxicities | Original drug (n = 38) | Generics (n = 43) | p |
|---|---|---|---|
| Hypersensitivity | 1 (2.6 %) | 0 (0 %) | 0.46 |
| Peripheral sensory neuropathy | 2 (5.3 %) | 7 (16.3 %) | 0.16 |
| Hematological toxicities | 5 (13.2 %) | 14 (32.6 %) | 0.04 |
| Febrile neutropenia | 1 (2.6 %) | 4 (9.3 %) | 0.36 |
| Gastrointestinal toxicity | 2 (5.3 %) | 6 (14 %) | 0.27 |
| Skin toxicity | 0 (0 %) | 5 (11.6 %) | 0.05 |
| Extra nail hypermelanosis | 0 (0 %) | 1 (2.3 %) | 1 |
| Hand foot syndrome grade III | 0 (0 %) | 3 (7 %) | 0.24 |
| Ichthyosis-like eruption | 0 (0 %) | 1 (2.3 %) | 1 |
| Treatment discontinuation | 3 (7.9 %) | 17 (39.5 %) | 0.001 |
Italic values indicate statistical significants