Table 2.
GSEA Analysis of miRNA Targeting in PCa
| Comparison | Gene Sets | NES | NOM P val | FDR Q val |
|---|---|---|---|---|
| Castrate-resistant vs castrate–sensitive cells | HALLMARK_E2F_TARGETS | 1.85 | .00 | .02 |
| HALLMARK_G2M_CHECKPOINT | 1.81 | .00 | .02 | |
| HALLMARK_MYC_TARGETS_V2 | 1.38 | .05 | .29 | |
| HALLMARK_MYC_TARGETS_V1 | 1.35 | .11 | .26 | |
| AR-negative vs AR-positive cells | HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | 2.18 | .00 | .01 |
| HALLMARK_GLYCOLYSIS | 1.94 | .00 | .01 | |
| HALLMARK_INTERFERON_GAMMA_RESPONSE | 1.91 | .00 | .01 | |
| HALLMARK_HYPOXIA | 1.87 | .00 | .01 | |
| HALLMARK_INTERFERON_ALPHA_RESPONSE | 1.83 | .03 | .01 | |
| HALLMARK_INFLAMMATORY_RESPONSE | 1.72 | .00 | .03 | |
| HALLMARK_IL6_JAK_STAT3_SIGNALING | 1.70 | .00 | .03 | |
| HALLMARK_IL2_STAT5_SIGNALING | 1.68 | .00 | .03 | |
| HALLMARK_APICAL_JUNCTION | 1.65 | .00 | .04 | |
| HALLMARK_ALLOGRAFT_REJECTION | 1.63 | .00 | .04 | |
| HALLMARK_UV_RESPONSE_DN | 1.60 | .03 | .04 | |
| HALLMARK_COMPLEMENT | 1.60 | .02 | .04 | |
| HALLMARK_ESTROGEN_RESPONSE_EARLY | 1.56 | .00 | .05 | |
| HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY | 1.54 | .01 | .06 | |
| HALLMARK_APOPTOSIS | 1.51 | .04 | .07 | |
| HALLMARK_COAGULATION | 1.51 | .08 | .07 | |
| HALLMARK_ESTROGEN_RESPONSE_LATE | 1.47 | .01 | .08 | |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | 1.45 | .00 | .09 | |
| HALLMARK_MITOTIC_SPINDLE | 1.44 | .04 | .09 | |
| HALLMARK_WNT_BETA_CATENIN_SIGNALING | 1.37 | .08 | .13 | |
| HALLMARK_MYOGENESIS | 1.36 | .11 | .14 | |
| HALLMARK_PROTEIN_SECRETION | 1.32 | .07 | .18 | |
| HALLMARK_MTORC1_SIGNALING | 1.31 | .14 | .17 | |
| HALLMARK_PI3K_AKT_MTOR_SIGNALING | 1.29 | .08 | .19 | |
| HALLMARK_TGF_BETA_SIGNALING | 1.25 | .20 | .22 | |
| HALLMARK_MYC_TARGETS_V2 | 1.24 | .16 | .22 | |
| HALLMARK_XENOBIOTIC_METABOLISM | 1.22 | .16 | .24 | |
| PCa vs other cancer cells | HALLMARK_OXIDATIVE_PHOSPHORYLATION | 1.66 | .01 | .21 |
| LNCaP vs LNCaP-MDV3100 | HALLMARK_P53_PATHWAY | 1.81 | .01 | .02 |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | 1.49 | .06 | .10 | |
| HALLMARK_MTORC1_SIGNALING | 1.34 | .12 | .15 | |
| HALLMARK_MYC_TARGETS_V1 | 1.22 | .21 | .21 |
NES indicates normalized enrichment score; FDR, false discovery rate. The P value represents a normal distribution.