Table 2.

Formate concentration in plasma and urine ± formate supplementation.

Strain	Plasma formate (μM)		Urine formate (μM/μM creatinine)
Controls	Formate-treated†	Control	Formate-treated††
Curly tail (ct/ct)	36.5 ± 3.6	600.3 ± 144.4	15.5 ± 2.8*	438.6 ± 199.6
Wild-type (+/+)	50.7 ± 5.4	1267.0 ± 564.0	47.8 ± 2.9	1884.9 ± 873.5

Formate concentration in urine of female ct/ct mice was significantly lower than in urine of wild-type mice (*p < 0.001). Among mice supplemented with 30 mg/ml formate in drinking water, the concentration of formate was significantly higher in plasma (†p < 0.01) and in urine (††p < 0.05) than in the equivalent non-supplemented controls (n = 3–4 mice in each group).