Table 1.

Effect of the HCM related TnT K280N mutation on Ca²⁺-sensitivity and phosphorylation dependence of Ca²⁺-sensitivity using the TnT K280N patient sample (see Fig. 1). X = exchanged. All data rounded to 2 significant figures.

	Experiment	EC50, μM		Ratio (EC50 Test/Control)	n	p	TnI Phosphorylation
	Test vs Control	Test	Control				Test	Control
A	Donor vs K280N patient	0.19 ± 0.015	0.20 ± 0.016	×0.99 ± 0.047	11	0.87	1.6 ± 0.060	1.4 ± 0.020
B	K280N vs dpK280N patient	0.14 ± 0.022	0.14 ± 0.024	×0.99 ± 0.020	6	0.54	1.4 ± 0.090	0.11 ± 0.10
C	Donor vs dpDonor	0.14 ± 0.030	0.050 ± 0.010	×3.1 ± 0.55	10	0.0040	1.6 ± 0.070	0.23 ± 0.070
D	K280N patientXTnT vs dpK280N patientXTnT	0.16 ± 0.035	0.088 ± 0.013	×1.8 ± 0.17	4	0.022	1.4 ± 0.12	0.090 ± 0.070