Table 3.

Effect of the HCM related TnT mutations on Ca²⁺-sensitivity and phosphorylation dependence of Ca²⁺-sensitivity (see Fig. 3, Fig. 4). All data rounded to 2 significant figures.

TnT mutation	EC50 WT μM ± SEM	EC50 mutant μM ± SEM	Ratio EC50 WT/mutant ± SEM	EC50 mutant P μM ± SEM	EC50 mutant dP μM ± SEM	Ratio EC50 P/dP
R92Q	0.12 ± 0.013	0.041 ± 0.00091	2.9 ± 0.28	0.072 ± 0.017	0.060 ± 0.012	1.1 ± 0.045
Δ14	0.22 ± 0.035	0.079 ± 0.0081	2.7 ± 0.16	0.055 ± 0.0031	0.055 ± 0.0032	1.0 ± 0.019
Δ28 + 7	0.097 ± 0.016	0.041 ± 0.0057	2.3 ± 0.068	0.054 ± 0.0041	0.055 ± 0.0037	1.0 ± 0.015
ΔE160	0.094 ± 0.0091	0.049 ± 0.0082	2.0 ± 0.30	0.052 ± 0.0046	0.053 ± 0.0056	1.0 ± 0.043
S179F	0.10 ± 0.0020	0.047 ± 0.00049	2.1 ± 0.020	0.059 ± 0.0030	0.057 ± 0.0038	1.1 ± 0.096
K273E	0.096 ± 0.0019	0.069 ± 0.024	1.6 ± 0.53	0.059 ± 0.0024	0.056 ± 0.0026	1.1 ± 0.014
K280N	0.17 ± 0.037	0.10 ± 0.020	1.7 ± 0.12	0.10 ± 0.0048	0.098 ± 0.0052	1.1 ± 0.037