Table 4.
Top 10 proteins detected by Multiplex Immunoassay analysis in medium from 0.25 μM fluoxetine-, 0.5 μM fluoxetine-treated and control embryos.
| Protein | UniProtKB | Control n = 10 | 0.25 μM fluoxetine n = 10 | 0.5 μM fluoxetine n = 10 | |||
|---|---|---|---|---|---|---|---|
| n | Median (range) | n | Median (range) | n | Median (range) | ||
| uPA | P00749 | 9 | 1.30 (0.40–3.20) | 10 | 1.15 (0.30–3.00) | 10 | 2.15 (0.90–3.40)* |
| IL-6 | P05231 | 8 | 1.35 (0.80– 3.20) | 10 | 1.50 (0.40–2.40) | 10 | 2.05 (0.50–4.90) |
| ADA | P00813 | 7 | 1.70 (1.10–2.30) | 5 | 1.40 (1.20–1.80) | 5 | 1.50 (1.10–1.80) |
| STAMPB | O95630 | 7 | 0.50 (0.40–1.10) | 4 | 0.45 (0.40–0.70) | 6 | 0.55 (0.40–1.00) |
| CST5 | P28325 | 6 | 0.10 (0.10–0.20) | 3 | 0.10 (0.10–0.10) | 1 | 0.10 (N/A) |
| FGF-23 | Q9GZV9 | 5 | 0.40 (0.30–0.40) | 6 | 0.35 (0.30–0.50) | 1 | 0.30 (N/A) |
| Beta-NGF | P01138 | 5 | 0.60 (0.40–1.50) | 2 | 0.25 (0.20–0.30) | ||
| IL-8 | P10145 | 4 | 0.15 (0.10–5.20) | 1 | 0.10 (N/A) | 5 | 1.30 (0.20–3.20) |
| IL-10 | P22301 | 4 | 0.40 (0.30–0.40) | 1 | 0.40 (N/A) | 1 | 0.10 (N/A) |
| VEGF-A | P15692 | 3 | 0.60 (0.10–1.80) | 6 | 0.80 (0.20–2.00) | 8 | 0.85 (0.20–1.70) |
*
P < 0.05 compared to 0.25 μM fluoxetine, Mann-Whitney U-test.