Table 6.
Allelic HLA-DRB1 frequencies among Brazilian pemphigus foliaceus and pemphigus vulgaris patients as compared to controls.
| HLA-DRB1⁎ | Controls (n=1592) | Pemphigus foliaceus (n=86) | Pemphigus vulgaris (n=82) |
|---|---|---|---|
| n (%) | n (%) | n (%) | |
| 01:01 | 150 (4.7) | 23 (13.4)a | 6 (3.7) |
| 01:02 | 113 (3.6) | 37 (21.5)b | 3 (1.8) |
| 01:03 | 22 (0.7) | 1 (0.6) | 0 |
| 03:01 | 247 (7.8) | 10 (5.8) | 4 (2.4) |
| 03:02 | 25 (0.8) | 3 (1.7) | 2 (1.2) |
| 04 | 0 | 2 (1.2) | 0 |
| 04:01 | 79 (2.5) | 3 (1.7) | 2 (1.2) |
| 04:02 | 65 (2.0) | 4 (2.3) | 42 (25.6)c |
| 04:03 | 38 (1.2) | 2 (1.2) | 4 (2.4) |
| 04:04 | 88 (2.8) | 10 (5.8) | 5 (3.1) |
| 04:05 | 63 (2.0) | 4 (2.3) | 1 (0.6) |
| 04:06 | 8 (0.3) | 1 (0.6) | 0 |
| 04:07 | 27 (0.9) | 1 (0.6) | 0 |
| 04:08 | 21 (0.7) | 2 (1.2) | 0 |
| 04:10 | 2 (0.1) | 0 | 0 |
| 04:11 | 54 (1.7) | 7 (4.1) | 2 (1.2) |
| 07:01 | 342 (10.7) | 6 (3.5) | 5 (3.1)d |
| 08:01 | 71 (2.2) | 0 | 2 (1.2) |
| 08:02 | 34 (1.1) | 3 (1.7) | 1 (0.6) |
| 08:03 | 10 (0.3) | 0 | 0 |
| 08:04 | 42 (1.3) | 2 (1.2) | 13 (7.9)e |
| 08:07 | 25 (0.8) | 1 (0.6) | 0 |
| 09:01 | 41 (1.3) | 4 (2.3) | 0 |
| 10:01 | 43 (1.4) | 1 (0.6) | 1 (0.6) |
| 11 | 0 | 0 | 1 (0.6) |
| 11:01 | 258 (8.1) | 1 (0.6)f | 9 (5.5) |
| 11:02 | 72 (2.3) | 1 (0.6) | 5 (3.1) |
| 11:03 | 31 (1.0) | 0 | 0 |
| 11:04 | 138 (4.3) | 1 (0.6) | 4 (2.4) |
| 11:06 | 1 (0.03) | 0 | 0 |
| 11:13 | 1 (0.03) | 0 | 0 |
| 11:18 | 1 (0.03) | 0 | 0 |
| 12:01 | 35 (1.1) | 3 (1.7) | 1 (0.6) |
| 12:02 | 3 (0.1) | 0 | 0 |
| 13:01 | 274 (8.6) | 3 (1.7)g | 4 (2.4) |
| 13:02 | 158 (5.0) | 2 (1.2) | 3 (1.8) |
| 13:03 | 55 (1.7) | 0 | 2 (1.2) |
| 13:05 | 2 (0.1) | 0 | 0 |
| 13:06 | 1 (0.03) | 0 | 0 |
| 13:21 | 1 (0.03) | 0 | 0 |
| 13:23 | 1 (0.03) | 0 | 0 |
| 13:31 | 1 (0.03) | 0 | 0 |
| 14:01 | 70 (2.2) | 0 | 25 (15.2)h |
| 14:02 | 35 (1.1) | 1 (0.6) | 3 (1.8) |
| 14:04 | 7 (0.2) | 2 (1.2) | 6 (3.7)i |
| 14:06 | 7 (0.2) | 1 (0.6) | 0 |
| 14:09 | 1 (0.03) | 0 | 0 |
| 15:01 | 194 (6.1) | 12 (7.0) | 2 (1.2) |
| 15:02 | 24 (0.8) | 0 | 2 (1.2) |
| 15:03 | 79 (2.5) | 5 (2.9) | 0 |
| 15:04 | 1 (0.03) | 0 | 0 |
| 15:11 | 1 (0.03) | 0 | 0 |
| 16:01 | 66 (2.1) | 10 (5.8) | 2 (1.2) |
| 16:02 | 56 (1.8) | 3 (1.7) | 2 (1.2) |
RR=relative risk, CI=confidence interval.
a
P=1×10−4, RR=2.83, 95% CI=1.88–4.28.
b
P=5×10−10, RR=6.06, 95% CI=4.32–8.49.
c
P=5.4×10−10, RR=12.54, 95% CI=8.79–17.88.
d
P=0.027, RR=0.28, 95% CI=0.12–0.67.
e
P=5.4×10−5, RR=6.0, 95% CI=3.29–10.97.
f
P=0.027, RR=0.07, 95% CI=0.01–0.50.
g
P=0.027, RR=0.20, 95% CI=0.06–0.62.
h
P=5.4×10−10, RR=7.21, 95% CI=4.72–10.99.
i
P=5.4×10−4, RR=16.64, 95% CI=5.65–48.95.