Table 3.
Multivariate associations of four SNPs in lincRNA-p21 gene with the risk of CAD or MI.
| Type | Controls | Cases | OR (95% CI)a versus controls | P a versus controls | |||
|---|---|---|---|---|---|---|---|
| Number (%) | CAD (%) | MI (%) | CAD | MI | CAD | MI | |
| n = 655 | n = 615 | n = 279 | |||||
| rs9380586 | |||||||
| G | 1177 (89.8) | 1104 (89.8) | 496 (88.9) | 1 | 1 | ||
| A | 133 (10.2) | 126 (10.2) | 62 (11.1) | 0.97 (0.72–1.32) | 1.12 (0.77–1.64) | 0.856 | 0.559 |
| GG | 531 (81.1) | 497 (80.8) | 223 (79.9) | 1 | 1 | ||
| AA+AG | 124 (18.9) | 118 (19.2) | 56 (20.1) | 1.00 (0.71–1.39) | 1.01 (0.66–1.54) | 0.986 | 0.981 |
| rs4713998 | |||||||
| A | 1035 (79.0) | 960 (78.0) | 431 (77.2) | 1 | 1 | ||
| G | 275 (21.0) | 270 (22.0) | 127 (22.8) | 1.05 (0.84–1.31) | 1.12 (0.77–1.64) | 0.686 | 0.231 |
| AA | 408 (62.3) | 374 (60.8) | 164 (58.8) | 1 | 1 | ||
| AG+GG | 247 (37.7) | 241 (39.2) | 115 (41.2) | 1.01 (0.77–1.32) | 1.01 (0.66–1.54) | 0.959 | 0.336 |
| rs6930083 | |||||||
| G | 951 (72.6) | 931 (75.7) | 425 (76.2) | 1 | 1 | ||
| A | 359 (27.4) | 299 (24.3) | 133 (23.8) | 0.86 (0.69–1.07) | 0.83 (0.62–1.10) | 0.177 | 0.200 |
| GG | 338 (51.6) | 349 (56.7) | 160 (57.3) | 1 | 1 | ||
| AG+AA | 317 (48.4) | 266 (43.3) | 119 (42.7) | 0.82 (0.63–1.07) | 0.79 (0.56–1.11) | 0.145 | 0.172 |
| rs6931097 | |||||||
| G | 799 (61.0) | 719 (58.5) | 327 (58.6) | 1 | 1 | ||
| A | 511 (39.0) | 511 (41.5) | 231 (41.4) | 1.12 (0.93–1.35) | 1.15 (0.89–1.47) | 0.246 | 0.286 |
| GG | 244 (37.3) | 204 (33.2) | 91 (32.6) | 1 | 1 | ||
| AA+AG | 411 (62.7) | 411 (66.8) | 188 (67.4) | 1.16 (0.88–1.52) | 1.19 (0.83–1.69) | 0.297 | 0.347 |
aAdjusted for sex, age, smoking, drinking, hyperlipidemia, hypertension, and diabetes.