Table 5.
Association between lincRNA-p21 gene haplotypes with the risk of premature CAD/MI.
| Haplotypea | Controls | Cases | OR (95% CI) | P |
|---|---|---|---|---|
| Number (%) | Number (%) | |||
| Premature CAD | n = 309 | n = 238 | ||
|
| ||||
| AAAG | 63.00 (10.2) | 56.77 (11.9) | 1.20 (0.82–1.76) | 0.344 |
| GAAG | 118.99 (19.3) | 65.29 (13.7) | 0.67 (0.48–0.93) | 0.017b |
| GAGA | 111.00 (18.0) | 95.23 (20.0) | 1.15 (0.85–1.56) | 0.364 |
| GAGG | 193.01 (31.2) | 167.71 (35.2) | 1.21 (0.94–1.56) | 0.142 |
| GGGA | 131.99 (21.4) | 88.06 (18.5) | 0.84 (0.62–1.14) | 0.263 |
|
| ||||
| Premature MI | n = 309 | n = 129 | ||
|
| ||||
| AAAG | 63.00 (10.2) | 29.68 (11.5) | 1.17 (0.73–1.85) | 0.514 |
| GAAG | 118.99 (19.3) | 34.16 (13.2) | 0.65 (0.43–0.99) | 0.041 |
| GAGA | 111.00 (18.0) | 44.31 (17.2) | 0.97 (0.66–1.42) | 0.859 |
| GAGG | 193.01 (31.2) | 96.85 (37.5) | 1.36 (1.00–1.84) | 0.049 |
| GGGA | 131.99 (21.4) | 48.84 (18.9) | 0.88 (0.61–1.27) | 0.484 |
aThe allelic sequence in the haplotypes is in the following order: rs9380586, rs4713998, rs6930083, rs6931097. Haplotype with frequency less than 3% was pooled and not analyzed.
b P values under 0.05 were shown in bold font.