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. 2016 Jun 2;2016:8434209. doi: 10.1155/2016/8434209

Figure 1.

Figure 1

Longitudinal fluctuations of serum active MMP-2 (a) and active MMP-9 and (b) TIMP-2 (c) and TIMP-1 (d) in patients with relapsing-remitting multiple sclerosis (RRMS) treated with Natalizumab for 21 months. MMP = matrix metalloproteinases; TIMP = tissue inhibitors of metalloproteinases; T0 = baseline; T3 = 3rd month; T6 = 6th month; T9 = 9th month; T12 = 12th month; T15 = 15th month; T18 = 18th month; and T21 = 21st month. Horizontal bars indicate medians and error bars correspond to interquartile range. The boundaries of the box represent the 25th–75th quartiles. The line within the box indicates the median. The whiskers above and below the box correspond to the highest and lowest values, excluding outliers.