Table 2.
Laboratory parameters at baseline and after 1 year
| Baseline | Azilsartan | Olmesartan | p value (Azilsartan vs. Olmesartan) |
|
|---|---|---|---|---|
| serum Creatinine (mg/dL) | 1.01 ± 0.29 | 1.03 ± 0.04 | 1.06 ± 0.05 | 0.496 |
| eGFR (mL/min/1.73m2) | 55.4 ± 1.6 | 53.8 ± 2.1 | 52.7 ± 2.4 | 0.715 |
| Urinary-albumin (mg/g ⋅ CRE) | 59.3 ± 14.5 | 49.1 ± 17.1 | 41.8 ± 13.5 | 0.491 |
| Cystatin-C (mg/L) | 1.17 ± 0.31 | 1.18 ± 0.04 | 1.20 ± 0.05 | 0.469 |
| Ox-LDL (U/L) | 91.1 ± 2.6 | 97.6 ± 7.2 | 79.6 ± 3.4 | 0.096 |
| EPA/AA | 0.55 ± 0.03 | 0.50 ± 0.05 | 0.57 ± 0.05 | 0.290 |
| RLP-cho (mg/dL) | 5.00 ± 0.34 | 5.12 ± 0.52 | 4.28 ± 0.34 | 0.185 |
| Total cholesterol (mg/dL) | 166.8 ± 3.1 | 168.3 ± 4.2 | 163.9 ± 3.3 | 0.414 |
| Triglycerides (mg/dL) | 129.1 ± 7.7 | 130.6 ± 12.1 | 115.8 ± 8.9 | 0.330 |
| Low density lipoprotein (mg/dL) | 91.9 ± 2.6 | 94.5 ± 3.7 | 89.7 ± 2.8 | 0.305 |
| High density lipoprotein (mg/dL) | 57.5 ± 1.3 | 58.7 ± 1.9 | 60.9 ± 1.9 | 0.410 |
| hs-CRP (mg/dl) | 0.20 ± 0.03 | 0.23 ± 0.05 | 0.45 ± 0.25 | 0.350 |
| ANP (pg/mL) | 48.0 ± 2.5 | 48.3 ± 4.1 | 48.3 ± 4.0 | 0.996 |
| BNP (pg/mL) | 67.4 ± 5.0 | 67.0 ± 7.6 | 62.9 ± 9.5 | 0.623 |
eGFR: estimated glomerular filtration rate; CRE: cretinine; Ox-LDL: oxidized low density lipoprotein; EPA/AA: eicosapentaenoic acid/arachidonic acid; RLP-cho: remnant like particles-cholesterol; hs-CRP: high-sensitivity C-reactive protein; ANP: atrial natriuretic peptide; BNP: brain natriuretic peptide