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. 2016 Jun 16;6:28182. doi: 10.1038/srep28182

Figure 1. NPY KO abolishes the anxiolytic effects of EE in the EPM.

Figure 1

(a) The number of open arm entries (interaction: F(1,32) = 5.150, P = 0.030; post-hoc test, *P < 0.05 vs. WT/SE; ###P < 0.001 vs. WT/EE) and (b) the time spent on the open arms of the EPM show an anxiolytic effect of EE only in WT animals (interaction: F(1,32) = 3.015, P = 0.092; post-hoc test, ##P < 0.01 vs. WT/EE). (c) The number of closed arm entries (significant main effect of genotype: F(1,32) = 18.283, P < 0.001), (d) the time spent on the closed arms (significant main effect of genotype: F(1,32) = 9.286, P = 0.005) and (e) total distance travelled (significant main effect of genotype: F(1,32) = 15.140, P < 0.001) reveal an hypo-explorative and hypo-locomotive phenotype of NPY KO mice. The time spent on the open and closed arms is expressed as percentage of the 5-min test duration. Values represent means ± SEM. ++P < 0.01, +++P < 0.001 for main effect: NPY KO vs. WT independently of housing condition; n = 9–10.