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. 2016 Jun 16;6:28182. doi: 10.1038/srep28182

Figure 3. EE impairs short-term memory of NPY KO mice.

Figure 3

(a) Schematic illustration of the Barnes maze. (b) The latency to find the target hole decreases for all mice upon repeated trials (significant main effect of trial: F(2.575,90.133) = 15.621, P < 0.001). NPY KO mice have higher target latencies (significant main effect of genotype: F(1,35) = 6.651, P = 0.014). (c) The latency to explore the first hole is higher for NPY KO mice during the first training trial (interaction: F(1.798,62.931) = 9.322, P < 0.001; Post-hoc test, ++P < 0.01 for main effect: NPY KO vs. WT independently of housing condition). (d) The number of primary errors tends to be lower in NPY KO mice (main effect of genotype: F(1,35) = 3.134, P = 0.085). (e,f) EE-housed NPY KO mice spend less time in the target quadrant during the probe trial (interaction: F(1,34) = 3.552, P = 0.068; post-hoc test, §§P < 0.01 vs. NPY/SE mice) 48 h (e), but not 9d (f) after the last training trial. Values represent means ± SEM; n = 9–10.