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. 2016 May 13;48(5):e233. doi: 10.1038/emm.2016.28

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Localization of glucocorticoid-induced transcript 1 (GLCCI1) in podocyte foot processes (FPs) by immunoelectron microscopy. (a) FPs formed by normal podocytes in the control group. (b) Effacement of FPs by podocyte injury in the diabetic group. Podocytes were disrupted by streptozotocin (STZ) treatment. (c) Podocyte FPs were regulated around the glomerular basement membrane (GBM) by treatment with wortmannin. Wortmannin could restore podocytes to their original condition. (d) Immunogold particles (arrowheads) marking GLCCI1 (10 nm gold) were observed in podocyte FPs of the control group. (e) No labeling was observed in podocyte FPs of the diabetic group. (f) Localization of GLCCI1 in podocyte FPs was observed in the wortmannin-treated diabetic group. Scale bar, 200 nm.