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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: Toxicol Lett. 2016 Jan 21;245:68–77. doi: 10.1016/j.toxlet.2016.01.012

Table 1.

Chemical levels for conventional and low-TSNA moist snuff products based on dry weight and per mg nicotine.

Dry weight basis per mg nicotine basis

Conventional moist snuff products (N=7) Low-TSNA moist snuff products (N=12) Conventional moist snuff products (N=7) Low-TSNA moist snuff products (N=12)

Chemical Mean SD Mean SD p-value Mean SD Mean SD p-value
Arsenic (μg/g)1,a 0.27 0.01 0.73 0.39 * 0.01 0.002 0.04 0.02 *
Benzo[a]pyrene (ng/g)1,a 77.75 24.90 1.47 1.38 **** 3.29 1.39 0.08 0.07 ****
Cadmium (μg/g)1,a 1.28 0.14 0.72 0.12 **** 0.05 0.01 0.04 0.01 **
Formaldehyde (μg/g)1,a 0.32 0.01 0.63 0.62 NS 0.01 0.00 0.03 0.03 NS
NNK (μg/g)1,a 1.55 0.73 0.31 0.12 **** 0.07 0.05 0.02 0.005 ****
NNN (μg/g)1,a 4.47 0.95 1.13 0.47 **** 0.19 0.07 0.06 0.01 ****
NDMA (μg/g)2A 0.69 1.22 0.21 0.26 NS 0.03 0.05 0.01 0.01 NS
Nitrate (mg/g)2A 27.76 4.13 9.72 2.75 **** 1.15 0.20 0.51 0.14 ****
Lead (μg/g)2B 0.46 0.19 0.65 0.38 NS 0.02 0.01 0.04 0.02 **
Nickel (μg/g)2B 3.24 0.46 1.75 0.71 ** 0.13 0.02 0.09 0.03 **
Chromium (μg/g)3 1.34 0.31 2.25 1.42 NS 0.06 0.01 0.13 0.07 **
NAB (μg/g)3 0.33 0.10 0.05 0.02 **** 0.01 0.005 0.003 0.001 ****
NAT (μg/g)3 4.99 2.01 0.71 0.25 **** 0.21 0.10 0.04 0.01 ****
Selenium (μg/g)3 0.27 0.01 0.28 0.14 NS 0.01 0.002 0.01 0.01 NS
Ammonia (mg/g) 8.92 3.25 1.34 0.59 **** 0.37 0.14 0.08 0.03 ****
Glycerol (mg/g) 0.58 0.89 8.56 17.46 NS 0.02 0.03 0.54 1.06 NS
Propylene Glycol (mg/g) 4.14 9.71 53.20 17.43 **** 0.16 0.36 3.04 1.24 ****
1

IARC Group1

2A

IARC Group2A

2B

IARC Group 2B

3

IARC Group 3

a

Harmful and Potentially Harmful Constituents established in smokeless tobacco by FDA

****

p<0.0001

*** 0.0001 to 0.001

**

0.001 to 0.01

*

0.01 to 0.05, NS not Significant