Table 1.
Dry weight basis | per mg nicotine basis | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Conventional moist snuff products (N=7) | Low-TSNA moist snuff products (N=12) | Conventional moist snuff products (N=7) | Low-TSNA moist snuff products (N=12) | |||||||
Chemical | Mean | SD | Mean | SD | p-value | Mean | SD | Mean | SD | p-value |
Arsenic (μg/g)1,a | 0.27 | 0.01 | 0.73 | 0.39 | * | 0.01 | 0.002 | 0.04 | 0.02 | * |
Benzo[a]pyrene (ng/g)1,a | 77.75 | 24.90 | 1.47 | 1.38 | **** | 3.29 | 1.39 | 0.08 | 0.07 | **** |
Cadmium (μg/g)1,a | 1.28 | 0.14 | 0.72 | 0.12 | **** | 0.05 | 0.01 | 0.04 | 0.01 | ** |
Formaldehyde (μg/g)1,a | 0.32 | 0.01 | 0.63 | 0.62 | NS | 0.01 | 0.00 | 0.03 | 0.03 | NS |
NNK (μg/g)1,a | 1.55 | 0.73 | 0.31 | 0.12 | **** | 0.07 | 0.05 | 0.02 | 0.005 | **** |
NNN (μg/g)1,a | 4.47 | 0.95 | 1.13 | 0.47 | **** | 0.19 | 0.07 | 0.06 | 0.01 | **** |
NDMA (μg/g)2A | 0.69 | 1.22 | 0.21 | 0.26 | NS | 0.03 | 0.05 | 0.01 | 0.01 | NS |
Nitrate (mg/g)2A | 27.76 | 4.13 | 9.72 | 2.75 | **** | 1.15 | 0.20 | 0.51 | 0.14 | **** |
Lead (μg/g)2B | 0.46 | 0.19 | 0.65 | 0.38 | NS | 0.02 | 0.01 | 0.04 | 0.02 | ** |
Nickel (μg/g)2B | 3.24 | 0.46 | 1.75 | 0.71 | ** | 0.13 | 0.02 | 0.09 | 0.03 | ** |
Chromium (μg/g)3 | 1.34 | 0.31 | 2.25 | 1.42 | NS | 0.06 | 0.01 | 0.13 | 0.07 | ** |
NAB (μg/g)3 | 0.33 | 0.10 | 0.05 | 0.02 | **** | 0.01 | 0.005 | 0.003 | 0.001 | **** |
NAT (μg/g)3 | 4.99 | 2.01 | 0.71 | 0.25 | **** | 0.21 | 0.10 | 0.04 | 0.01 | **** |
Selenium (μg/g)3 | 0.27 | 0.01 | 0.28 | 0.14 | NS | 0.01 | 0.002 | 0.01 | 0.01 | NS |
Ammonia (mg/g) | 8.92 | 3.25 | 1.34 | 0.59 | **** | 0.37 | 0.14 | 0.08 | 0.03 | **** |
Glycerol (mg/g) | 0.58 | 0.89 | 8.56 | 17.46 | NS | 0.02 | 0.03 | 0.54 | 1.06 | NS |
Propylene Glycol (mg/g) | 4.14 | 9.71 | 53.20 | 17.43 | **** | 0.16 | 0.36 | 3.04 | 1.24 | **** |
IARC Group1
IARC Group2A
IARC Group 2B
IARC Group 3
Harmful and Potentially Harmful Constituents established in smokeless tobacco by FDA
p<0.0001
*** 0.0001 to 0.001
0.001 to 0.01
0.01 to 0.05, NS not Significant