Table 2.
Probabilistic cancer risk estimates for conventional and low-TSNA moist snuff products based on dry weight and per mg nicotine.
| Dry weight basis | per mg nicotine basis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Conventional moist snuff products (N=7) | Low-TSNA moist snuff products (N=12) | Conventional moist snuff products (N=7) | Low-TSNA moist snuff products (N=12) | |||||||
| Chemical | Mean | SD | Mean | SD | p-value | Mean | SD | Mean | SD | p-value |
| Benzo[a]pyrene1,a | 2.95E-07 | 9.44E-08 | 5.57E-09 | 5.25E-09 | **** | 1.25E-08 | 5.26E-09 | 2.82E-10 | 2.46E-10 | **** |
| Cadmium1,a | 2.17E-04 | 2.29E-05 | 1.23E-04 | 1.99E-05 | **** | 8.99E-06 | 1.19E-06 | 6.77E-06 | 1.51E-06 | ** |
| Formaldehyde1,a | 5.20E-06 | 1.47E-07 | 1.02E-05 | 1.02E-05 | NS | 2.16E-07 | 3.70E-08 | 5.40E-07 | 5.21E-07 | NS |
| NNK1,a | 8.06E-04 | 3.79E-04 | 1.60E-04 | 6.01E-05 | **** | 3.53E-05 | 2.43E-05 | 8.62E-06 | 2.78E-06 | **** |
| NNN1,a | 2.43E-03 | 5.17E-04 | 6.17E-04 | 2.55E-04 | **** | 1.03E-04 | 3.55E-05 | 3.25E-05 | 7.12E-06 | **** |
| NDMA2A | 1.58E-04 | 2.80E-04 | 4.90E-05 | 5.87E-05 | NS | 6.60E-06 | 1.09E-05 | 2.68E-06 | 3.67E-06 | NS |
| Lead2B | 3.35E-08 | 1.41E-08 | 4.76E-08 | 2.78E-08 | NS | 1.38E-09 | 5.57E-10 | 2.55E-09 | 1.36E-09 | ** |
| NAB3 | 1.36E-06 | 4.11E-07 | 2.20E-07 | 9.26E-08 | **** | 5.68E-08 | 2.08E-08 | 1.17E-08 | 4.06E-09 | **** |
1
IARC Group1
2A
IARC Group2A
2B
IARC Group 2B
3
IARC Group 3
a
Harmful and Potentially Harmful Constituents established in smokeless tobacco by FDA
****
p<0.0001
***0.0001 to 0.001
**
0.001 to 0.01
* 0.01 to 0.05, NS not Significant