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. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Reduced muscle strength and locomotor activity. a Mecp2 ^−/Y rats exhibited decreased forelimb grip strength compared to WT (***P < 0.001, **P < 0.01, *P < 0.05; Student’s t test). b In comparison to the WT, both Mecp2 ^−/Y rats and mice showed a significant decrease in grip strength (Student’s t test). c No statistical significance in the grip strength differences was found between species after normalization to the WT levels. d, e Locomotor activity was also significantly reduced in Mecp2 ^−/Y rodents. No statistical significance was found between species either, although the null rats appeared to move less (Student’s t test)