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. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Social behavior defects of Mecp2 ^−/Y rats. a, b The habituation time in side chambers had no significant difference in Mecp2 ^−/Y animals and WT littermates. c, d The time spending of both Mecp2 ^−/Y animals in the intruder chamber (Animal 1) was more than in the empty bucket chamber (Empty). e, f The animal preference disappeared in both Mecp2 ^−/Y animals. Familiar animal is indicated as Animal 1, and unfamiliar animal is labeled as Animal 2. (***P < 0.001, **P < 0.01, * P < 0.05; Student’s t test)