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. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Increased excitability of LC neurons. a, b Typical recordings of spontaneous firing activity in WT and Mecp2 ^−/Y rat LC neurons. c In Mecp2 ^−/Y rats, LC neurons showed a significant increase in firing frequency in comparison to the WT. d The ratio of increased spontaneous firing rate, however, was similar between rats and mice. e, f No significant differences were found in membrane potential and resistance between WT and Mecp2 ^−/Y rats, which was similar as in the mice model. g, h In comparison to the WT, Mecp2 ^−/Y rats showed more hyperpolarized threshold of the action potential in LC neurons, whereas the amplitude was not altered. Similar results were found in the mouse model (**P < 0.01,*P < 0.05; Student’s t test)