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. 2016 Jun 16;4:60. doi: 10.1186/s40478-016-0331-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Kaplan-Meier survival plots. a Diffuse gliomas of WHO G7rade II separated by ATRX status (n = 130); median: 2141 days in ATRX loss group vs. 1175 days in ATRX retention group. b Astrocytoma WHO grade II and III grouped (n = 176), tumors harbouring ATRX loss (n = 96) had a significantly better outcome compared to tumors with ATRX retention (n = 80) (median: 1952 vs. 818 days, p < 0.0001) c Astrocytic, oligodendroglial and mixed tumors without 1p/19q codeletion (n = 230) show a significant better outcome when accompanied with ATRX loss than with ATRX retention (median ATRX loss 1769 days vs. ATRX retention 1127 days, p = 0.0046)