Table 2. Summary of studies.
|
Reference (publication year) |
Number of patients and controls (years) |
Sample, analyzer, method |
Platelet indices |
P |
Study design |
Comment |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Patients |
Controls |
|||||||||||||
|
Acute Appendicitis (adults) | ||||||||||||||
|
Albayrak et al. (2011) |
226 patients with AA (2.5 ± 15.1) and 206 controls (35.5 ± 14.7) |
ND, Beckman Coulter analyzer, impedance |
MPV: 7.25 ± 0.85 fL |
MPV: 9.01 ± 1.33 fL |
Decreased* (P < 0.001) |
Diagnostic, case-control, prospective |
CBC analysed within 2 hours after collection. Best cut-off point for MPV in the diagnosis of AA was ≤ 7.6 fL. |
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|
Tanrikulu et al. (2014) |
239 patients with AA and 21 patients with normal appendix were included jointly in the patient group (31.8 ± 12.4); 158 controls (32.2 ± 10.5) |
ND |
MPV: 7.75 ± 1.24 fL |
MPV: 8.49 ± 0.97 fL |
Decreased* (P < 0.001) |
Diagnostic, case-control, retrospective, multicenter study |
Best cut-off point for MPV in the diagnosis of AA was ≤ 7.3 fL. |
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|
Erdem et al. (2015) |
100 patients with AA (33.6 ± 12.2) and 100 controls (30.8 ± 9.7) |
ND |
MPV: 7.4 ± 0.9 fL |
MPV: 9.1 ± 1.6 fL |
Decreased* (P < 0.001) |
Diagnostic, case-control, retrospective |
CBCs analysed 24 hours prior to surgery. Best cut-off point for MPV in the diagnosis of AA was ≤ 7.95 fL. |
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|
Dinc et al. (2015) |
295 patients with AA and 100 patients with other intra-abdominal infections; 100 controls (16–94) |
EDTA-anticoagulated blood, ND |
MPV (fL) in AA patients 8.5 (6.1–14.2); MPV (fL) in patients with intra-abdominal infection 8.9 (6.0–13); PDW (%) in AA patients 18.4 (10.3–62.5); PDW (%) in patients in intra-abdominal infection 40.8 (12.8–87.9) |
MPV: 8.9 (6.9–14.5) fL; PDW 49.0 (10.6 -86.5)% |
MPV decreased* (P = 0.001); PDW increased† (P < 0.001) |
Diagnostic, case-control, retrospective |
All samples analysed within 10 minutes. Diagnostic accuracy for PDW was 96.0%. |
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|
Yang et al. (2014) |
196 AA patients (41.8 ± 15.5) and 143 controls (44.0 ± 10.3) |
EDTA-anticoagulated blood, Advia 2120 (Siemens Healthcare Diagnostics, Germany), optical method |
MPV: 7.82 ± 0.64 fL |
MPV: 7.96 ± 0.58 fL |
Decreased* (P = 0.042) |
Diagnostic, case-control, retrospective |
CBC analysed within 2 hours after collection. |
|||||||
|
Reference (publication year) |
Number of patients and controls (years) |
Sample, analyzer, method |
Platelet indices |
P |
Study design |
Comment |
||||||||
|
Patients |
Controls |
|||||||||||||
|
Fan et al. (2015) |
160 gangrenous AA patients (43.0 ± 12.5) and 160 healthy controls (45.6 ± 19.6) |
EDTA-anticoagulated blood, ND |
MPV: 9.21 ± 1.38 fL; PDW: 15.25 ± 1.90% |
MPV: 10.91 ± 2.72 fL; PDW: 12.5 ± 1.93% |
MPV decreased* (P = 0.000); PDW increased† (P = 0.000) |
Diagnostic, case-control, retrospective |
All samples analysed within 10 minutes. Best cut-off point for MPV in the diagnosis of AA was ≤ 9.6fL. Best cut-off point for PDW in the diagnosis of AA was ≥ 15.1fL. |
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|
Narci et al. (2013) |
503 patients (34.7 ± 14.1) and 121 controls (35.2 ± 8.1) |
Cell-Dyne 3700 (Abbott Diagnostics, IL, USA), impedance |
MPV: 7.92 ± 1.68 fL |
MPV: 7.43 ± 1.34 fL |
Increased† (P < 0.001) |
Diagnostic, case-control, retrospective |
Best cut-off point for MPV in the diagnosis of AA was ≥ 7.87 fL |
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|
Bozkurt et al. (2015) |
Patients operated for appendectomy were divided into three groups: 90 uncomplicated AA; 120 complicated AA and 65 negative appendectomy (17–78) |
Sysmex XT-2000i (Sysmex Corporation, Kobe, Japan), impedance and optic |
MPV in uncomplicated AA patients 10.40 ± 0.93 fL; MPV in complicated AA 10.27 ± 0.93 fL; MPV in negative appendectomy patients 10.42 ± 1.00 fL |
None |
Not changed (P =0.478) |
Diagnostic, case-control, retrospective |
Best cut-off point for MPV in the diagnosis of AA was ≥ 10.8 fL. |
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|
Lee et al. (2011) |
130 female AA patients (43.4 ± 16.6) and 85 female controls (45.1 ± 12.1) |
ND |
MPV: 10.58 ± 0.80 fL |
MPV: 10.04 ± 0.83 fL |
Not changed (P = 0.285) |
Diagnostic, case-control, retrospective |
- |
|||||||
|
Kucuk et al. (2015) |
60 patients (33.15 ± 10.94) |
Cell-Dyne 3700 (Abbott Diagnostics, IL, USA), impedance |
MPV: in AA patients 7.03 ± 0.8 fL; previous MPV: 7.58 ± 1.11 fL |
None |
Decreased* (P = 0.01) |
Diagnostic, case-series, retrospective |
Previous MPV of the same patient was evaluated as control. |
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|
Kılıç et al. (2015) |
316 AA patients and 316 controls (14–76) |
EDTA-anticoagulated blood, LH 780 Analyzer (Beckman Coulter Inc., USA), impedance |
MPV: 8.03 (5.53–14.40) fL |
MPV: 8.10 (5.70–13.90) fL |
Not changed (P = 0.193) |
Diagnostic, case-control, retrospective |
CBC analyses were performed within 2 hours after collection. |
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|
Aktimur et al. (2015) |
407 AA patients and 61 patients with normal appendix (range 16–86) |
ND |
MPV in AA patients 9.6 ± 1.5 fL; MPV in negative appendectomy 9.1 ± 1.5 fL |
None |
Increased (P = 0.018) |
Diagnostic, case-control, retrospective |
For cut-off value of 9.6 fL, sensitivity was 57.1% and specificity was 60.7%. |
|||||||
|
Reference (publication year) |
Number of patients and controls (years) |
Sample, analyzer, method |
Platelet indices |
P |
Study design |
Comment |
||||||||
|
Patients |
Controls |
|||||||||||||
|
Sexana D et al. (2015) |
Attempted to define potential thresholds value which is predictive of a diagnosis in 213 AA patients. |
ND |
ND |
None |
Diagnostic retrospective |
When they used an MPV cut-off value of ≤ 7.6 fL, they found sensitivity, specificity and accuracy of which was 83.73%, 75% and 83.56%, respectively |
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|
Acute appendicitis (pediatric) | ||||||||||||||
|
Bilici S et al. (2011) |
100 AA patients (8.1 ± 3.4) and 100 controls (8.7 ± 3.6) |
EDTA-anticoagulated blood, ABX-Pentra DX 120 (ABX-Horiba, France), impedance |
MPV: 7.55 ± 0.89 fL |
MPV: 8.90 ± 1.29 fL |
Decreased* (P = 0.001) |
Diagnostic, case-control, retrospective |
CBC was analyzed 2 hours after blood collection. Specificity was 54% and sensitivity was 87% for MPV at ≤ 7.4 fL. |
|||||||
|
Uyanik et al. (2012) |
305 AA patients (9.5 ± 2.9) and 305 controls (9.6 ± 3.1) |
EDTA-anticoagulated blood, ND |
MPV: 7.9 ± 0.9 fL |
MPV: 7.7 ± 0.8 fL |
Not changed (P > 0.05) |
Diagnostic, case-control, retrospective |
CBC analyses were performed within 1 hour after collection. |
|||||||
|
Yilmaz et al. (2015) |
204 AA patients (10.4 ± 3.7) and 20 subjects with normal appendix vermiformis (10.9 ± 4.2) |
EDTA-anticoagulated blood, Mindray BC-5800 (Mindray BioMedical Electronics Co., Ltd., China), iImpedance |
MPV in AA patients 7.37 ± 0.9 fL; MPV in negative appendectomy 7.60 ± 1.24 fL; PCT in AA patients 0.220 ± 0.057; PCT in negative appendectomy 0.208 ± 0.045; PDW in AA patients 16.3 ± 0.5; PDW in negative appendectomy 16.4 ± 0.7 |
None |
Not changed (P > 0.05) for MPV, PCT and PDW |
Diagnostic, case-control |
The number of patients with normal appendix vermiformis was too small. |
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|
Acute cholecystitis | ||||||||||||||
|
Seker et al. (2013) |
33 patients with AC (56.4 ± 15.7), 32 patients with CC (51.4 ± 13.8), 28 controls (54.7 ± 9.61) |
ND |
MPV in AC patients 6.38 ± 0.88 fL; MPV in CC patients 7.78 ± 0.75 fL |
MPV: 7.88 ± 0.74 fL |
Decreased* (P < 0.05) |
Case-control Retrospective |
The number of patients was too small. |
|||||||
|
Reference (publication year) |
Number of patients and controls (years) |
Sample, analyzer, method |
Platelet indices |
P |
Study design |
Comment |
||||||||
|
Patients |
Controls |
|||||||||||||
|
Acute mesenteric ischemia (AMI) | ||||||||||||||
|
Türkoğlu et al. (2015) |
95 patients who underwent emergency surgery for acute mesenteric ischemia (68.4 ± 14.4) and 90 controls (67.1 ± 15.7) |
EDTA-anticoagulated blood, Cell-Dyne 3700 (Abbott Diagnostics,IL, USA), impedance |
MPV: 9.4 ± 1.1 fL |
MPV: 7.4 ± 1.4 fL |
(P < 0.001) |
Case-control Retrospective |
The best cut-off point for MPV in the diagnosis of AA was > 8.1 fL |
|||||||
|
Altıntoprak et al. (2013) |
30 patients operated for AMI (29–94), two groups according to outcome – non-survivors (group 1) and survivors (group 2) |
ND |
MPV in non-survivors: 9.01 fL; MPV in survivors: 7.80 fL |
None |
(P = 0.002) |
Prognostic, retrospective |
SDs were not given |
|||||||
|
Aktimur et al (2015) |
62 AMI related laparotomy and/or bowel resection patients (41–93 yrs), 62 AA patients (14–86), 61 negative appendectomy patients (16–73) |
ND |
MPV in AMI patients 10.8 ± 0.9 fL; MPV in AA patients 10.5 ± 0.8 fL; MPV in negative appendectomy patients 9.1 ± 1.5 fL |
None |
(P < 0.001) |
Retrospective |
The median ages were significantly different. CBCs were taken 24 hours prior to surgery. |
|||||||
|
Bilgiç et al. (2015) |
61 patients operated for AMI (40–91); two groups according to outcome: Survivors (53–87) and non-survivors (40–91) |
ND |
Non-survivor MPV: 8.4 (5.5 –10.4) fL; survivor MPV: 7.6 (6.6–8.9) fL |
None |
(P < 0.01) |
Prognostic, retrospective |
Cut-off point for mortality in AMI was MPV = 8.1 fL. Sensitivity, specificity, positive and negative predictive values were 60%, 73.1%, 74.7%, and 58%, respectively. |
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| Age is presented as mean age ± standard deviation or age range. Platelet indices are presented as mean ± standard deviation or mean (range). AA – acute appendicitis; MPV – mean platelet volume; CC – chronic cholecystitis; AMI – acute mesenteric ischemia; CBC – complete blood count; ND – not declared; decreased * – decreased compared to healthy controls; increased † – increased compared to healthy controls. | ||||||||||||||