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. 2016 Jun 20;129(12):1439–1446. doi: 10.4103/0366-6999.183434

Figure 4.

Figure 4

(a) The fluorescence intensity of cells staining with annexin V/FITC and propidium iodide. (b) The proportion of apoptotic cell death significantly increased in BHT-101 cells transfected with pcDNA-BASP1 for 24 h or 48 h. (c) The proportion of apoptotic cell death significantly increased in KMH-2 cells transfected with pcDNA-BASP1 for 24 h or 48 h. (d) Overexpression of BASP1 induced the expression of bax and cytosolic cytochrome C, while decreased bcl-2 and mitochondrial cytochrome C expression. PARP, the substrate of caspase-3, was also detected. *P < 0.05, pcDNA-BASP1 versus the control. BASP1: Brain acid soluble protein 1; PARP: Poly ADP-ribose polymerase.