Table 4.
Characteristics of Serum Lactate Level Cutoff Values for Complete Case Analysis and Imputation Analysis Using Surviving Sepsis Campaign Database
| Characteristic | Serum Lactate Level, mmol/L
|
|||||
|---|---|---|---|---|---|---|
| >2
|
>3
|
>4
|
||||
| Died/Total | % (95% CI) | Died/Total | % (95% CI) | Died/Total | % (95% CI) | |
| Complete Case Analysis (n = 18 795) | ||||||
|
| ||||||
| Hospital mortality, % | 5757/18 795 | 30.6 (29.9–31.4) | 6101/18 795 | 32.5 (31.8–33.2) | 6456/18 975 | 34.3 (33.7–35.0) |
|
| ||||||
| Sensitivity, % | 5372/6509 | 82.5 (81.6–83.4) | 3779/6509 | 58.1 (56.8–59.3) | 2811/6509 | 43.2 (42.0–44.4) |
|
| ||||||
| Specificity, % | 2748/12 286 | 22.4 (21.6–23.1) | 6418/12 286 | 52.2 (51.4–53.1) | 8564/12 286 | 69.7 (68.9–70.5) |
|
| ||||||
| PPV, % | 5372/14 910 | 36.0 (35.3–36.8) | 3779/9647 | 39.2 (38.2–40.2) | 2811/6533 | 43.0 (41.8–44.2) |
|
| ||||||
| NPV, % | 2748/3885 | 70.7 (69.3–72.2) | 6418/9148 | 70.1 (69.2–71.1) | 8564/12 286 | 69.8 (69.0–70.7) |
|
| ||||||
| Imputed Missing Serum Lactate Level (n = 22 182) | ||||||
|
| ||||||
| Hospital mortality, % | 6965/22 182 | 31.4 (30.8–32.0) | 7363/22 182 | 33.2 (32.6–33.8) | 7772/22 182 | 35.0 (34.4–35.7) |
|
| ||||||
| Sensitivity, % | 6457/7748 | 83.3 (82.5–84.2) | 4461/7748 | 57.6 (56.5–58.7) | 2931/7748 | 37.8 (36.7–38.9) |
|
| ||||||
| Specificity, % | 3341/14 434 | 23.1 (22.5–23.8) | 7833/14 434 | 54.3 (53.5–55.1) | 10 801/14 434 | 74.8 (74.1–75.5) |
|
| ||||||
| PPV, % | 6457/17 550 | 36.8 (36.1–37.5) | 4461/11 062 | 40.3 (39.4–41.2) | 2931/6564 | 44.6 (43.4–45.8) |
|
| ||||||
| NPV, % | 3341/4634 | 72.1 (70.8–73.4) | 7833/11 120 | 70.4 (69.6–71.3) | 10 801/15 618 | 69.2 (68.4–69.9) |
Abbreviations: NPV, negative predictive value; PPV, positive predictive value.
SI conversion factor: To convert serum lactate values tomg/dL, divide by 0.111.