Table 5.
Crude Mortality in Septic Shock Groups From UPMC and KPNC Data sets
| Variablea | Highest Serum Lactate Levels 24 h After Infection Identified, mmol/L | UPMC
|
KPNC
|
||||
|---|---|---|---|---|---|---|---|
| No. (%) (n = 5984) | Acute Hospital Mortality
|
No. (%) (n = 54 135) | Acute Hospital Mortality
|
||||
| No. | % (95% CI) | No. | % (95% CI) | ||||
| Group 1 | >2 (all) | 315 (5.3) | 171 | 54.3 (48.6–59.9) | 8051 (14.9) | 2835 | 35.2 (34.2–36.3) |
|
| |||||||
| >3 | 246 (4.1) | 147 | 59.8 (53.3–65.9) | 6006 (11.1) | 2355 | 39.2 (38.0–40.5 | |
|
| |||||||
| >4 | 189 (3.2) | 120 | 63.5 (56.2–70.4) | 4438 (8.2) | 1939 | 43.7 (42.2–45.2) | |
|
| |||||||
| Group 2 | ≤2 | 147 (2.5) | 37 | 25.2 (18.4–33.0) | 3094 (5.7) | 582 | 18.8 (17.4–20.2) |
|
| |||||||
| Group 3 | >2 (all) | 3544 (59.2) | 1278 | 36.1 (34.5–37.7) | 12 781 (23.6) | 2120 | 16.6 (15.9–17.2) |
|
| |||||||
| >3 | 2492 (41.6) | 1058 | 42.5 (40.5–44.4) | 6417 (11.9) | 1381 | 21.5 (20.5–22.5) | |
|
| |||||||
| >4 | 1765 (29.5) | 858 | 48.6 (46.3–51.0) | 3316 (6.1) | 914 | 27.6 (26.0–29.1) | |
|
| |||||||
| Groups 4 and 5 | >2 (all) | 1978 (33.1) | 355 | 17.9 (16.3–19.7) | 30 209 (55.8) | 2061 | 6.8 (6.5–7.1) |
|
| |||||||
| >3 | 1033 (17.3) | 224 | 21.7 (19.2–24.3) | 12 450 (23.0) | 1138 | 9.1 (8.6–9.7) | |
|
| |||||||
| >4 | 566 (9.4) | 146 | 25.8 (22.2–29.6) | 5394 (9.9) | 637 | 11.8 (11.0–12.7) | |
Abbreviations: KPNC, Kaiser Permanente Northern California; SSC, Surviving Sepsis Campaign; UPMC, University of Pittsburgh Medical Center.
SI conversion factor: To convert serum lactate values tomg/dL, divide by 0.111.
Group 1 refers to patients with hypotension + vasopressors + serum lactate levels greater than 2 mmol/L. Group 2 refers to patients with hypotension + vasopressors + serum lactate levels less than 2 mmol/L. Group 3 refers to patients with hypotension and serum lactate levels greater than 2 mmol/L. Groups 4 and 5 refer to isolated serum lactate level greater than 2 mmol/L. Counts within a group are not mutually exclusive, as those with serum lactate levels greater than 2 mmol/L will include those in the higher serum lactate cutoffs.