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. Author manuscript; available in PMC: 2016 Jun 16.
Published in final edited form as: Bioorg Med Chem. 2015 Jun 14;23(15):4489–4500. doi: 10.1016/j.bmc.2015.06.012

Table 4.

Inhibition of [3H]MK-801 binding to rat cortical membranes by pentamidine analogs with additional aromatic rings

IC50 ± SD (n) (µM) Ratio
no spm 30 µM spm
graphic file with name nihms790883t4.jpg 4.23 ± 2.47
(4)		 7.48 ± 2.51
(4)		 2.37 ± 1.69
(4)
graphic file with name nihms790883t5.jpg 6.97 ± 2.15
(3)		 24.0 ± 19.2
(3)		 3.47 ± 2.20
(3)
graphic file with name nihms790883t6.jpg 12.2
(2)		 30.7
(2)		 2.56
(2)
graphic file with name nihms790883t7.jpg 5.34
(2)		 6.76
(2)		 1.50
(2)
graphic file with name nihms790883t8.jpg 6.68 ± 1.25
(4)		 17.7 ± 6.3
(4)		 2.61 ± 0.61
(4)
graphic file with name nihms790883t9.jpg 9.9 ± 4.4
(3)		 34.2
(2)		 4.63
(2)
graphic file with name nihms790883t10.jpg 3.21
(2)		 13.4
(2)		 4.14
(2)
graphic file with name nihms790883t11.jpg 5.01 ± 3.28
(3)		 11.7
(2)		 4.26
(2)
graphic file with name nihms790883t12.jpg 26.8 ± 13.1
(3)		 30.0 ± 6.7
(3)		 1.24 ± 0.38
(3)

Definitions as in caption to Table 1.