Table 3.
Adverse effects experienced.
| Adverse effects |
|||
|---|---|---|---|
| Experienced n (%) | Most significant n (%) | One of 3 most significant n (%) | |
| Clozapine-induced side-effects | |||
| Hypersalivation | 90 (91.8) | 7 (7.1) | 24 (24.5) |
| Drowsiness | 61 (62.2) | 13 (13.3) | 30 (30.6) |
| Fatigue | 55 (56.1) | 11 (11.2) | 23 (23.5) |
| Weight gain | 47 (48.0) | 13 (13.3) | 26 (26.5) |
| Gastrointestinal upset | 31 (31.6) | 6 (6.1) | 14 (14.3) |
| Dizziness | 29 (29.6) | 3 (3.1) | 9 (9.2) |
| Restless legs | 22 (22.4) | 2 (2.0) | 6 (6.1) |
| Urinary incontinence or retention | 20 (20.4) | 1 (1.0) | 5 (5.1) |
| Tachycardia | 17 (17.3) | 2 (2.0) | 3 (3.1) |
| Tremor | 15 (15.3) | 1 (1.0) | 3 (3.1) |
| Rigidity | 14 (14.3) | 0 (0.0) | 1 (1.0) |
| Agitation | 11 (11.2) | 2 (2.0) | 4 (4.1) |
| Headache | 10 (10.2) | 1 (1.0) | 4 (4.1) |
| Hypertension | 8 (8.2) | 0 (0.0) | 1 (1.0) |
| Seizures | 7 (7.1) | 2 (2.0) | 2 (2.0) |
| Skin reactions | 7 (7.1) | 0 (0.0) | 0 (0.0) |
| Other* | 7 (7.1) | 2 (2.0) | 7 (7.1) |
*
Included sexual dysfunction, insomnia, dysphagia, reduced appetite or abnormal taste in mouth.