Table VII.

Part I of Sensitivity Analysis. Multivariable Analysis to determine predictors of Eczema Based on Clinician’s Diagnosis at Age 4 Years^†±

	N Eczema/N Total (% with Eczema)	Adjusted Odds ratio [95% CI]	p-value
History of parental eczema	32/115 (28%)	2.4 [1.4–4.4]	0.003
Egg ingestion before age 1 year	71/426 (17%)	0.9 [0.5–1.6]	0.7
Sensitization to egg (age 1 year)	27/72 (38%)	4.3 [2.2–8.5]	<0.001
Sensitization to elm (ages 1,2, and/or 3 years)	16/55 (29%)	2.1 [0.9–5.1]	0.1
Interaction Terms
Dog in home (before age 1; n=197)‡
SPT+ to Dog (ages 1,2, and/or 3)	4/17 (24%)	2.6§	0.2
versus		[0.7–9.9]
SPT− to Dog (ages 1,2, and/or 3)	24/180 (13%)
No Dog in home (before age 1; n=319)
SPT+ to Dog (ages 1,2, and/or 3)	14/33 (42%)	1.8	0.2
versus		[0.7–4.8]
SPT− to Dog (ages 1,2, and/or 3)	51/286 (18%)
Cat in home (before age 1; n=120) ‡
SPT+ to Cat (ages 1,2, and/or 3)	9/18 (50%)	7.4§	0.002
versus		[2.2–25.3]
SPT− to Cat (ages 1,2, and/or 3)	14/102 (14%)
No Cat in home (before age 1; n=402)
SPT+ to Cat (ages 1,2, and/or 3)	17/58 (29%)	0.6	0.4
versus		[0.3–1.6]
SPT− to Cat (ages 1,2, and/or 3)	55/344 (16%)

^†Total cohort size was 636 children at age four; 107 children (18%) met criteria for eczema based on the clinician’s diagnosis

^‡28 (26%) children with eczema based on the clinician’s diagnosis owned dogs; 23 (21%) owned cats; based on the home visit

^§Represents adjusted odds ratio for eczema based on the interaction between pet ownership and skin prick test (SPT)

^±Table E3 represents covariates that remained in the final model after backward elimination with an alpha cut-off of 0.15.