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. Author manuscript; available in PMC: 2016 Jun 16.

Published in final edited form as: Hum Hered. 2014 Jul 8;78(1):47–58. doi: 10.1159/000363411

Table 6.

Significant associations of common SNPs with metabolic syndrome phenotypes

Gene	SNP	BMI	WC	HC	SBP	DBP	Chol	HDL	LDL	VLDL	TG	ALT	AST
ADCY5	rs11708067	0.0359	0.0395	0.0477
CRY2	rs11605924								0.0388				0.0308^*
FADS1	rs174550							0.0209		0.0056	0.0023
FTO	rs8050136	0.0096	0.0121	0.0031
FTO	rs3751812	0.0010	0.0023	0.0002
FTO	rs9939609	0.0100	0.0216	0.0042
FTO	rs7203051									0.0415
GCK	rs4607517				0.0413
GLIS3	rs7034200							0.0361		0.0175	0.0391
HNF1B	rs4430796	0.0278						0.0175		0.0493
IGF2BP2	rs4402960					0.0281
JAZF1	rs864745						0.0420						0.0440
LOC100128217	rs2191349										0.0532
MADD	rs7944584		0.0053^*					0.0074^*
MTNR1B	rs10830963									0.0015^*	0.0018^*
PROX1	rs340874											0.0500
SLC2A2	rs11920090	0.0218						0.0050			0.0345
SLC30A8	rs13266634	0.0013^*	0.0031^*	0.0060^*	0.0229^*					0.0492^*	0.0455
SLC30A8	rs11558471	0.0028^*	0.0127^*	0.0154^*	0.0182^*
TCF7L2	rs7901695	0.0311^*				0.0158		0.0263^*		0.0168	0.0057^*	0.0035^*
TCF7L2	rs4506565	0.0406^*				0.0089		0.0286^*		0.0189	0.0064^*	0.0036^*
TCF7L2	rs7903146	0.0102^*	0.0151^*			0.0148		0.0042^*		0.0068	0.0027	0.0049^*
TCF7L2	rs12243326	0.0250^*						0.0131^*		0.0076^*	0.0032^*
TCF7L2	rs12255372							0.0142^*			0.0165^*
THADA	rs7578597					0.0048^*	8.8 × 10⁻⁵^*		0.0003^*	0.0165^*	0.0285^*		0.0243

Both corrected (p ≤ 0.0015; in bold) and uncorrected (p ≤ 0.05) p values for multiple testing by trait are shown, p values are nominal and from MGA;

^*

p values are from QTDT because of the presence of population stratification.