Table 2. Effects of 24 h, 48 h and 6 days exposures to TBBPA on IL -1 β secretion from monocyte depleted PBMCs.

24 h	Interleukin 1 beta secreted in pg/mL (mean±S.D.)
[TBBPA] μM	F 175	F 177	F 180	F 184
0	1751±31	1103±43	4465±8	714±103
0.05	1417±142*	2393±457*	4807±139*	6869±345*
0.1	1198±23*	1898±446	4088±79*	5478±856*
0.25	1527±106	1098±19-	2777±33*	1743±233*
0.5	1409±73*	608±219	2268±178*	1294±36*
1	778±30*	670±58*	1645±157*	1311±635*
2.5	790±71*	308±41*	957±129*	938±±34
5	578±18*	179±50*	1544±80*	737±125
48 h	Interleukin 1 beta secreted in pg/mL (mean±S.D.)
[TBBPA] μM	F 175	F 177	F 180	F 184
0	3086±173	2381±189	5539±216	618±35
0.05	3061±338	2178±124	4826±229*	765±166
0.1	2691±354	1918±48*	4212±129*	595±115
0.25	1850±140*	2220±263	2726±167*	720±93
0.5	3045±116	1918±24*	2563±79*	573±94
1	3014±102	1480±1128	2720±239*	601±10
2.5	1594±77*	1371±48*	2475±56*	1415±93*
5	1178±31*	1272±15*	4680±117*	2347±81*
6d	Interleukin 1 beta secreted in pg/mL (mean±S.D.)
[TBBPA] μM	F 175	F 177	F 180	F 184
0	1458±15	3054±253	2960±128	371±26
0.05	4149±113*	13725±175*	2938±108	2975±450*
0.1	3238±42*	3025±78	2321±168*	1894±336*
0.25	2918±192*	5479±189*	1857±234*	1998±263*
0.5	2468±137*	4000±113*	780±55*	1360±156*
1	1417±22	2167±69*	1285±110*	1429±88*
2.5	3426±82*	2646±182	1915±135*	1348±302*
5	559±21*	1946±71*	1951±41*	1544±81*

Values are mean±S.D. of triplicate determinations.

^*Indicates a significant change in secretion compared to control cells (cells treated with vehicle alone), p<0.05