Table 5.

Effects of 24 h, 48 h and 6 days exposures to HBCD on IL -1 β secretion from monocyte depleted PBMCs.

24 h	Interleukin 1 beta secreted in pg/mL (mean±S.D.)
[HBCD] μM	F 196	F 198	F 202	F 204	F 212
0	13357±405	472±99	1159±534	3248±156	140±6
0.05	10959±136*	2159±247*	2439±308*	3969±146*	3169±134*
0.1	13819±434	1344±159*	1568±279	2825±31*	3231±168*
0.25	11888±181*	1316±267*	1815±210	4327±86*	3264±111*
0.5	16171±389*	820±159*	3095±703*	3914±279*	3730±166*
1	15914±328*	2358±84*	9492±1378*	6735±105*	2004±283*
2.5	22644±1785*	22427±539*	38224±568*	23059±1288*	12008±448*
5	27027±2079*	26757±1975*	47052±5925*	33407±291*	18484±279*
48 h	Interleukin 1 beta secreted in pg/mL (mean±S.D.)
[HBCD] μM	F 196	F 198	F 202	F 204	F 212
0	10065±167	732±241	2869±597	2527±88	51±32
0.05	18636±372*	742±285	2791±444	3927±379*	1421±533*
0.1	17737±344*	56±44*	2180±219	3556±329*	480±21*
0.25	16910±249*	993±193	4024±310	3556±183*	1458±147*
0.5	14375±522*	182±44	5013±296*	3725±300*	2259±38*
1	12735±600*	2356±243*	8458±403*	10214±89*	1715±59*
2.5	15908±1214*	31196±5128*	28980±2137*	53843±1168*	14834±566*
5	13784±844*	44452±2611*	47813±3328*	45151±3390*	30639±4459*
6d	Interleukin 1 beta secreted in pg/mL (mean±S.D.)
[HBCD] μM	F 196	F 198	F 202	F 204	F 212
0	7442±59	160±76	4064±69	3343±155	214±69
0.05	7432±374	846±124*	4057±261	6941±359*	5149±325*
0.1	7971±278	255±16	9114±310*	5941±398*	2398±80*
0.25	7442±394	2779±194*	8739±239*	4146±68*	1624±372*
0.5	7471±187	427±167	11306±370*	8437±39*	1754±219*
1	7898±305	2341±119*	21896±563*	9385±393*	5248±122*
2.5	12643±449*	25341±635*	26080±960*	22685±796*	17777±791*
5	6471±203*	34027±586*	33038±2129*	25531±312*	23356±60*9

Values are mean±S.D. of triplicate determinations.

^*Indicates a significant change in secretion compared to control cells (cells treated with vehicle alone), p<0.05