Table 4.

Methodological quality of ITS study included in the review.

Author	Was the intervention independent of other changes?	Was the shape of the intervention effect pre-specified?	Was the intervention unlikely to affect data collection?	Was knowledge of the allocated interventions adequately prevented during the study?	Were incomplete outcome data adequately addressed?	Was the study free from selective outcome reporting?	Was the study free from other risks of bias?	Overall risk of bias
Richmond et al.28	Low risk	Low risk	High risk	Low risk	Unclear risk	High risk	High risk	High

ITS: interrupted time series.