Table 2. ACMG list of hereditary cancer syndromes, most with childhood onset, for reporting incidental findings.
| Syndrome | Gene | Inheritance |
|---|---|---|
| Li-Fraumeni | TP53 | AD |
| Peutz-Jeghers | STK11 | AD |
| Familial adenomatous polyposis | APC | AD |
| Von-Hippel Lindau | VHL | AD |
| Multiple endocrine neoplasia | MEN1 (type 1); RET (type 2) | AD |
| Hamartomatosis | PTEN | AD |
| Retinoblastoma | RB | AD |
| Paraganglioma-pheochromocytoma | SDHAF2, SDHB, SDHC, SDHD | AD |
| Tuberous sclerosis complex | TSC1, TSC2 | AD |
| Neurofibromatosis type 2 | NF2 | AD |
| WT1-related Wilms tumor | WT1 | AD |
AD, autosomal dominant.