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. 2016 Jun 3;39(2):203–209. doi: 10.1590/1678-4685-GMB-2014-0351

Table 2. Costs of the TP53-p.R337H analysis for one patient.

Description HRMc PCR-RFLP TaqMan-PCR DNA Sequencing
Total cost (R$)a 18.84 19.86 26.28 53.29
Fold increase of costb 1.00 1.05 1.39 2.83
a

includes DNA isolation, quantification, all steps of each method and professional labor cost for handling and result interpretation

b

in relation to the least expensive method

c

HRM is a screening method and not a direct genotyping method as PCR-RFLP, TaqMan and Sanger sequencing (see Figure 2 for further details on additional cost).